Histological study of the occipital bone from patients with Chiari I malformation

Tubbs, R.S., Benzie, A.L., Rizk, E., Chern, J.J., Loukas, M., Oakes, W.J., 2015a. Histological study of the occipital bone from patients with Chiari I malformation. Childs Nerv Syst. doi:10.1007/s00381-015-2907-z.

Abstract

BACKGROUND:
This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition.

METHODS:
Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis.

RESULTS:
For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples.

CONCLUSIONS:
Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.