Histological study of the occipital bone from patients with Chiari I malformation

Tubbs RS, Benzie AL, Rizk E, Chern JJ, Loukas M, Oakes WJ.Histological study of the occipital bone from patients with Chiari I malformation.Childs Nerv Syst. 2016 Feb;32(2):351-3. doi: 10.1007/s00381-015-2907-z. 

ABSTRACT

BACKGROUND:

This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition.

METHODS:

Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis.

RESULTS:

For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples.

CONCLUSIONS:

Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.