Neuroanatomical variation in autism spectrum disorder: A comprehensive review

Jumah F, Ghannam M, Jaber M, Adeeb N, Tubbs RS.Neuroanatomical variation in autism spectrum disorder: A comprehensive review.Clin Anat. 2016 May;29(4):454-65. doi: 10.1002/ca.22717.


Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in socialization, communication, and behavior. Many investigators have described the anatomical abnormalities in autistic brains, in an attempt to correlate them with the manifestations of ASD. Herein, we reviewed all the available literature about the neuroanatomical findings in ASD available via "PubMed" and "Google Scholar." References found in review articles were also searched manually. There was substantial discrepancy throughout the literature regarding the reported presence and significance of neuroanatomical findings in ASD, and this is thoroughly discussed in the present review.